Walker, M.C. mSphere of Influence: Synthetic Biology of Natural Product Biosynthesis. mSphere 2020, 5, e00954-19.
Mentored Publications
Walker, M.C., Eslami, S.M., Hetrick, K.J., Ackenhusen, S.E., Mitchell, D.A., and van der Donk, W.A. Precursor peptide-targeted mining of more than one hundred thousand genomes expands the lanthipeptide natural product family. BMC Genomics. 2020, 21, 387.
Hegemann, J.D., Bobeica, S.C., Walker, M.C., Bothwell, I.R., and van der Donk, W.A. Assessing the flexibility of the prochlorosin 2.8 scaffold for cyclic peptide library generation. ACS Synth. Biol. 2019, 8(5), 1204-1214.
Hetrick, K.J.*, Walker, M.C.*, and van der Donk, W.A. Development and application of yeast and phage display of diverse lanthipeptides. ACS Cent. Sci. 2018, 4(4), 458-467.
Yang, X., Lennard, K.R., He, C., Walker, M.C., Ball, A.T., Tavassoli, A., and van der Donk, W.A. Generation and screening of a lanthipeptide library for inhibitors of the p6/UEV protein-protein interaction. Nat. Chem. Biol. 2017, 14(4), 375.
Ortega, M.A., Hao, Y., Walker, M.C., Donadio, S., Sosio, M., Nair, S.K., and van der Donk, W.A. Structure and tRNA specificity of MibB, a lantibiotic dehydratase from actinobacteria involved in NAI-107 biosynthesis. Cell Chem. Biol. 2016, 23(3), 370-380.
Walker, M.C. and van der Donk, W.A. The many roles of glutamate in metabolism. J. Ind. Microbiol. Biotechnol. 2015, 43(2), 419-430.
Zhang, Q., Doroghazi, J.R., Zhao, X., Walker, M.C., and van der Donk, W.A. Expanded natural product diversity revealed by analysis of lanthipeptide-like gene clusters in actinobacteria. Appl. Environ. Microbiol. 2015, 81(13), 4339-4350.
Ortega, M.A., Hao, Y., Zhang, Q., Walker, M.C., van der Donk, W.A., and Nair, S.K. Structure and mechanism of the tRNA-dependent lantibiotic dehydratase NisB. Nature 2015, 517(7535), 509-512.
Walker, M.C. and Chang, M.C.Y. Natural and engineered biosynthesis of fluorinated natural products. Chem. Soc. Rev. 2014, 43(18), 6527-6536.
Walker, M.C.*, Thuronyi, B.W.*, Charkoudian, L.K., Khosla, C., and Chang, M.C.Y. Expanding the fluorine chemistry of living systems using engineered polyketide synthase pathways. Science 2013, 341(6150), 1089-1094.
Walker, M.C., Wen, M., Weeks, A.M., Chang, M.C.Y. Temporal and fluoride control of secondary metabolism regulates cellular organofluorine biosynthesis. ACS Chem. Biol. 2012, 7(9), 1576-1585.
Brown, M.E., Walker, M.C., Nakashige, T.G., Iavarone, A.T., Chang, M.C.Y. Discovery and characterization of heme enzymes from unsequenced bacteria: application to microbial lignin degradation. J. Am. Chem. Soc. 2011, 133(45), 18006-18009.
*contributed equally.
M.C. Walker Lab @ UNM 